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Advanced Melanoma
Lifileucel
Tumour Infiltrating Lymphocyte
Table of contents
**Updates**
We updated this drug summary on 15th of April 2025, removed 'Snippets at a glance', removed TLDR section, added simple definitions, and condensed longer paragraphs into summary points to improve readability.
What is lifileucel used for?
Blocks cancer growth by using the patient’s own immune cells.
Treats advanced melanoma (skin cancer that cannot be removed by surgery or has spread) after other treatments fail.
Melanoma - A serious type of skin cancer that starts in the pigment-producing cells.
Immune cells - White blood cells that fight infections and diseases.
What is the mechanism of action of lifileucel?
Doctors remove part of the tumor to extract cancer-fighting immune cells
T cells - Immune cells that recognise and destroy harmful cells, including cancer.
IV (intravenous infusion) - Delivering medicine or cells directly into a vein.
What are the contraindications of lifileucel?
Immune system - The body’s defence against germs and diseases.
Infections - Illnesses caused by bacteria, viruses, or other germs.
Side effects - Unwanted or negative things that can happen when we take medicine or get treatment.
Important lifileucel prescribing safety information.
Patients need chemotherapy (e.g., cyclophosphamide) to prepare the body for Lifileucel.
Lifileucel can cause severe drops in blood cells (platelets, white blood cells)
Lymphodepletion - Chemotherapy to clear space for new immune cells.
Platelets - Small blood cells that help our body form clots to stop bleeding.
Lifileucel patient counselling advice.
Weak immunity - When the body struggles to fight infections.
Hygiene - Practices like handwashing to stay clean and healthy.
Good self-care - In this instance meaning maintaining good hydration, eating a balanced diet, and getting adequate rest to help manage side effects.
References
References
1. Iovance Biotherapeutics (n.d.). Highlights of Prescribing Information. [online] Available at: https://www.fda.gov/media/176417/download?attachment [Accessed 4 Jun. 2024]. Link
2. Iovance Biotherapeutics (n.d.). Patient Information AMTAGVI (lifileucel). [online] Available at: https://www.iovance.com/AMTAGVI_Patient_Information/ [Accessed 4 Jun. 2024]. Link
3. Parums, D.V. (2024). Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi). Medical science monitor, 30. doi:https://doi.org/10.12659/msm.944927. Link
4. Sarnaik, A.A., Hamid, O., Khushalani, N.I., Lewis, K.D., Medina, T., Kluger, H.M., Sajeve Samuel Thomas, Evidio Domingo-Musibay, Pavlick, A.C., Whitman, E.D., Martín-Algarra, S., Corrie, P., Curti, B.D., Judit Oláh, Lutzky, J., Weber, J.S., Larkin, J., Shi, W., Takamura, T. and Madan Jagasia (2021). Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma. journal of clinical oncology, 39(24), pp.2656–2666. doi:https://doi.org/10.1200/jco.21.00612. Link
5. www.amtagvi.com. (n.d.). AMTAGVI (Lifileucel) Learn about AMTAGVI (Lifileucel). [online] Available at: https://www.amtagvi.com/receiving/ [Accessed 4 Jun. 2024]. Link